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  • It can take a few weeks to notice improvement in your depression – do not stop taking imipramine in the belief that it is not working.
  • Your doctor may ask you to carry on taking imipramine after you feel better – this is to help stop your depression from returning.
  • When taken for night-time bed-wetting, imipramine is usually taken for up to three months.

About imipramine

Type of medicine Tricyclic antidepressant
Used for Treatment of depression
Treatment of night-time bed-wetting in children
Also called Imipramine hydrochloride
Available as Tablets

Imipramine works by preventing chemicals called serotonin and noradrenaline from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of these chemicals, and so helps relieve depression.

Imipramine helps relieve bed-wetting by blocking certain receptors in the wall of the bladder and preventing a chemical called acetylcholine from acting on these receptors. Acetylcholine normally causes the bladder to empty, so by stopping this action, imipramine reduces the need to pass urine.


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