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Diabetes – Diabetic Retinopathy

What is diabetic retinopathy?

What is diabetes?

Diabetes mellitus (just called diabetes from now on) occurs when the level of glucose (sugar) in the blood becomes higher than normal. There are two main types of diabetes – type 1 and type 2. See leaflets called ‘Diabetes Type 1’ and ‘Diabetes Type 2’ for more general information about diabetes.

What is the retina?

The retina is made up from special cells called rods and cones which line the back of your eyes. Light enters your eye and passes through the lens which focuses the light on to the retina. Messages about what you see are then passed from the cells in the retina to the optic nerve, and on to the brain. Many tiny blood vessels in the retina take oxygen and nutrients to the cells of the retina.

What is retinopathy?

The term retinopathy covers various disorders of the retina, which can affect vision. Retinopathy is usually due to damage to the tiny blood vessels in the retina. Retinopathy is commonly caused by diabetes, but is sometimes caused by other diseases such as very high blood pressure.

Note: people with diabetes also have a higher risk of developing other eye problems, including cataracts and glaucoma. These will not be discussed in this leaflet.

How does diabetic retinopathy occur?

Over several years, a high blood glucose (sugar) level can weaken and damage the tiny blood vessels in the retina. This can result in various problems which include:

  • Small blow-out swellings of blood vessels (microaneurysms).
  • Small leaks of fluid from damaged blood vessels (exudates).
  • Small bleeds from damaged blood vessels (haemorrhages).
  • Blood vessels may just become blocked. This can cut off the blood and oxygen supply to small sections of the retina.
  • New abnormal blood vessels may grow from damaged blood vessels. This is called proliferative retinopathy. These new vessels are delicate and can bleed easily.

The leaks of fluid, bleeds and blocked blood vessels may damage the cells of the retina. In some severe cases, damaged blood vessels bleed into the vitreous humour (the jelly-like centre of the eye). This can also affect vision by blocking light rays going to the retina.

What symptoms does diabetic retinopathy cause?

Most people with diabetic retinopathy do not have any symptoms or visual loss due to their retinopathy. However, without treatment, diabetic retinopathy can gradually become worse and lead to visual loss or even blindness. Diabetic retinopathy is the most common cause of blindness in people of working age in the UK.

Initial symptoms that may occur include blurred vision, seeing floaters and flashes, or even having a sudden loss of vision.

Different types of diabetic retinopathy

Different parts of the retina can be affected

The macula is a small part of the retina which is roughly in the centre at the back of the eye. The macula is where you focus your vision. So, when you read or look at an object, the light focuses on the macula. The central and most important part of the macula is called the fovea. The outer part of the retina is used for peripheral vision.

Retinopathy can affect the macula, the peripheral (outer part) of the retina, or both. It is much more serious if the macula is affected.

The severity of the retinopathy can vary

Retinopathy usually develops gradually and tends to become worse over a number of years:

  • Background retinopathy does not change your sight. With this you have some tiny microaneurysms, tiny leaks of fluid and tiny bleeds in various parts of the retina. A doctor or optometrist can see these as tiny dots and blots on the retina when they examine the back of the eye.
  • Pre-proliferative retinopathy is more extensive than background retinopathy. There are signs of blood flow becoming restricted, but not yet showing new blood vessels growing (see below).
  • Maculopathy is when there is damage to your macula.
  • Proliferative retinopathy occurs when damaged blood vessels in the retina make chemicals called growth factors. These can cause new tiny blood vessels to grow (proliferate) from the damaged blood vessels. This is an attempt to repair the damage. However, these new blood vessels are not normal. They are delicate, and can easily bleed, obscuring your vision. In this type of retinopathy, without laser treatment, vision is likely to become badly affected.

    If the proliferative retinopathy becomes severe then many abnormal new blood vessels grow. They may block the drainage channels in your eye, causing glaucoma, or accompanying fibre growth may cause the retina to detach from the back of the eye.

The effects of retinopathy may be different in each eye. Also, if you have high blood pressure in addition to diabetes, it can make retinopathy worse or progress more quickly.

Who gets diabetic retinopathy?

Retinopathy is a common complication of diabetes. It is more common in people with type 1 diabetes.

Risk factors for diabetic retinopathy include:

  • Duration of diabetes. The longer you have had diabetes, the higher your risk of developing retinopathy. It is uncommon if you have had diabetes for less than five years. However, around 9 in 10 people who have had diabetes for longer than 30 years can be affected.
  • Poor glucose control. Studies have shown that those people with poor control of their diabetes are more likely to develop all complications, including retinopathy. However, one large study has shown that even a proportion of people who have very well-controlled glucose levels still develop diabetic retinopathy in the future.
  • High blood pressure. If your blood pressure is not well-controlled then this will increase your risk of developing retinopathy.
  • Nephropathy (kidney disease). Having kidney disease as a result of your diabetes is associated with worsening retinopathy.
  • Pregnancy. Being pregnant may make retinopathy worsen, especially if your blood glucose is poorly controlled.
  • Other risk factors include smoking, obesity and having a high cholesterol level.

Can diabetic retinopathy be prevented?

You are less likely to develop retinopathy or, if you have mild (background) retinopathy it is less likely to progress to more serious retinopathy, if:

  • Your blood glucose level is well-controlled. Treatment to control blood glucose is discussed in other leaflets on diabetes. Briefly, it involves: a healthy diet, losing weight if you are overweight, regular exercise and medication if required.
  • Your blood pressure and cholesterol levels are well-controlled.

Some studies also suggest that smoking may make retinopathy worse. Therefore, you are also advised to stop smoking if you smoke.

Eye checks for diabetic retinopathy

Treatment can prevent loss of vision and blindness in most cases. Therefore, if you have diabetes, it is vital that you have regular eye checks to detect retinopathy before your vision becomes badly affected. You should have an eye check at least once a year.

In the UK, the NHS offers a free annual screening appointment each year to all people with diabetes, over the age of 11. Make sure that you get your appointment each year and tell your doctor if you do not.

The annual screening test includes:

  • Testing your vision.
  • Taking digital photographs of your retina (to compare with previous examinations).

To examine your eyes properly you will have drops put into your eyes to make the pupil as wide as possible. The drops can make your vision blurry for up to six hours. This can affect your ability to drive so you should not drive to or from the place where the test is carried out.

Another test which is sometimes done at the eye hospital, when retinopathy is suspected, is a fluorescein angiogram. This involves having a special dye injected into one of the veins in your arm. This dye then travels to the blood vessels in your eye. A camera with a special filter is used to show up any swollen, leaking or abnormal blood vessels.

If you are found to have no retinopathy or mild (background) retinopathy, and your vision is not affected, then you are likely just to be invited back for screening in 12 months’ time. The retinopathy may not progress to more serious forms, particularly if your diabetes and blood pressure are well-controlled. If more severe changes are detected, you may be referred to an eye specialist for a detailed eye examination, and treatment if necessary.

Even if your check shows you do not have any retinopathy then you should still look after your diabetes and have a healthy lifestyle to reduce the risk of a retinopathy developing in the future.

Note: if you notice any change in your vision before you are due a routine check, you should tell your doctor or optometrist who will arrange an eye check earlier.

What is the treatment for diabetic retinopathy?

If you have mild diabetic retinopathy then you will not usually require any treatment other than controlling any other risk factors (for example, blood pressure, glucose and cholesterol levels).

Laser treatment

Laser treatment is used mainly if you have new vessels growing (proliferative retinopathy), or if any type of retinopathy is affecting the macula. A laser is a very bright light that is very focused so it makes tiny burns on whatever it is focused on. A burn can seal leaks from blood vessels, and stop new vessels from growing further. The burns are so tiny and accurate that they can treat a tiny abnormal blood vessel. Several hundred burns may be needed to treat retinopathy.

There are different types of lasers. The type chosen may depend upon your actual eye condition. It is common to need several treatment sessions.

Treatment usually works well to prevent retinopathy from getting worse, and so often prevents loss of vision, or blindness. However, laser treatment cannot restore vision that is already lost.

You may find after your laser treatment that your sight may become dim or blurred. This normally improves over the following few days.

Other treatments

Various eye operations may be needed if you have a bleed into the vitreous humour or develop a detached retina (which are possible consequences of severe retinopathy). An operation may also occasionally be needed if your laser treatment has not been successful.

The treatment of diabetic retinopathy is a developing area of medicine. Some studies have shown benefits with various newer treatments. (See the references at the end for details.) However, these are not yet widely available and further research is needed to determine their place in the treatment of diabetic retinopathy.

Further help and information

Diabetes UK

10 Parkway, London, NW1 7AA
Tel: 0845 120 2960
Web: www.diabetes.org.uk
Diabetes UK is the largest organisation in the UK working for people with diabetes, funding research, campaigning and helping people to live with the condition.

References and Disclaimer | Provide feedback

References

  • Bhavsar AR et al, Diabetic Retinopathy, Medscape, Oct 2011
  • Ockrim Z, Yorston D; Managing diabetic retinopathy. BMJ. 2010 Oct 25;341:c5400. doi: 10.1136/bmj.c5400.
  • Arevalo JF, Garcia-Amaris RA; Intravitreal bevacizumab for diabetic retinopathy. Curr Diabetes Rev. 2009 Feb;5(1):39-46. [abstract]
  • Wong TY, Liew G, Tapp RJ, et al; Relation between fasting glucose and retinopathy for diagnosis of diabetes: three Lancet. 2008 Mar 1;371(9614):736-43. [abstract]
  • Emerson MV, Lauer AK; Emerging therapies for the treatment of neovascular age-related macular BioDrugs. 2007;21(4):245-57. [abstract]
  • Lopes de Jesus CC, Atallah AN, Valente O, et al; Pentoxifylline for diabetic retinopathy. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD006693. [abstract]

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