Bowen’s Disease

Understanding the skin

The skin has two layers – the epidermis (or outer layer) and the dermis (or inner layer). Beneath the dermis is a layer of fat and then the deeper structures such as muscles and tendons.

The epidermis has three main types of cell:

  • Basal cells. These are the bottom layer of cells in the epidermis.
  • Keratinocytes. These cells are in layers above the basal layer. They make a substance called keratin which is a hard waxy material. Keratinocytes are constantly dividing and a certain number are dying at any given time. The top (horny) layer of the epidermis is made of dead keratinocytes which contain keratin. The top of the skin is constantly being shed and replaced by new dead cells which contain keratin.
  • Melanocytes. These cells are dotted about at the bottom of the epidermis. They make a pigment called melanin when skin is exposed to sun. The melanin is passed to the nearby skin cells to protect them from the sun’s rays. Melanin causes the skin to tan in fair-skinned people. Dark-skinned people have more active melanocytes.

What is Bowen’s disease?

Bowen’s disease is named after the dermatologist (skin specialist) who first described it in 1912. It occurs when there is a growth of abnormal cells in the epidermis. These abnormal cells are just confined within the epidermis and have not spread to the dermis or elsewhere.

It is not a skin cancer but can sometimes develop into a skin cancer if the abnormal cells spread deeper and outside of the epidermis. Some doctors refer to Bowen’s disease as a pre-cancer because it has the potential to develop into a cancer. It may also be called a type of ‘carcinoma in situ‘. Carcinoma means cancer and in situ means in its place in latin. (That is, the abnormal cells have not spread outside the epidermis so there is no sign of an invading cancer.)

It is estimated that around 3 in 100 patches of Bowen’s disease can develop into a true skin cancer called a squamous cell carcinoma.

It used to be thought that people with Bowen’s disease had an increased risk of having a cancer somewhere else in their body. If you like, it was seen as a sign of an internal cancer. However, recent studies have shown that this is not the case. Bowen’s disease is not a sign that you have a cancer somewhere else in your body.

What are the symptoms of Bowen’s disease?

Bowen’s disease is typically a red-looking patch of skin that has an irregular outline. It tends to look crusty or scaly. Sometimes the patch of Bowen’s disease can become cracked or ulcerated and can bleed. Patches can slowly enlarge. Patches of Bowen’s disease may be a few millimetres in diameter but, in some cases, can grow to several centimetres in diameter. Sometimes, in its early stages, Bowen’s disease can be mistaken for other skin problems such as ringworm, psoriasis or a type of eczema. The picture shows a typical patch of Bowen’s disease on a leg.

Bowen’s disease more commonly appears on areas of the skin that have been exposed to the sun. In about three quarters of cases, it occurs on the leg, below the knee. It may also appear on your neck or face and it may be found under or around your nails. Bowen’s disease can also occur on covered areas of skin. It may be found on the palms of your hands, on the soles of your feet, around your anus and in your genital area.

Bowen’s disease-type skin patches that occur on the genital areas may be given some different names. For example, Bowen’s disease that occurs on the penis is called ‘erythroplasia of Queyrat’.

Most people just have one patch of Bowen’s disease but between 1 to 2 in 10 people can have more than one patch at the same time.

If a patch of Bowen’s disease starts to become ulcerated, bleeds, or if a small bump appears, this could possibly be a sign that it has started to change into a skin cancer. See your doctor as soon as possible if this happens. Bowen’s disease affecting your genitals or around your anus may be more likely to develop into a skin cancer than Bowen’s disease in other places.

What causes Bowen’s disease?

A patch of Bowens disease can appear for no apparent reason and can affect anyone. However, there are a number of different things that are thought to increase your risk of developing Bowen’s disease. These include:

  • Excessive sun exposure.
  • Previous radiotherapy treatment, for example for cancer.
  • Immunosupression. If your immune system is not working well for some reason, this can increase your risk of Bowen’s disease. For example if you have AIDS, if you are undergoing treatment for cancer, or if you have had an organ transplant such as a kidney transplant and have had drugs to suppress your immune system to prevent organ rejection.
  • Infection with the human papillomavirus (HPV). This is a virus that can affect your skin and mucosa (the moist membranes that line different parts of your body, including your mouth, throat and genital area). There are over one hundred types of HPV. Some types of HPV can cause skin warts and verrucas, others can cause genital warts but many types do not cause any problems at all. Some types of HPV are known to increase the risk of developing particular cancers including cervical cancer. It is thought that HPV may also be involved in the development of both genital Bowen’s disease and Bowen’s disease affecting other parts of the skin. HPV type 16 is most commonly associated. However, not everyone with Bowen’s disease has HPV infection.
  • A previous injury to the skin. If you have had an injury to your skin that has caused chronic (persistent) skin damage or scarring, this may increase your risk of developing Bowen’s disease in that area.
  • Inflammatory skin conditions. Rarely, people with chronic skin inflammation problems such as eczema can develop Bowen’s disease.

How common is Bowen’s disease?

Around 14 per 100,000 people in the UK are thought to develop Bowen’s disease each year.

Who gets Bowen’s disease?

Bowen’s disease seems to be more common in women than in men. It most commonly affects people aged in their 60s. It is more common in people with white skin and in areas of the skin that have been exposed to the sun.

You may also be more likely to develop Bowen’s disease if you have previously had one of a group of skin cancers called non-melanoma skin cancers. These are skin cancers that are not malignant melanoma. They include basal cell carcinoma and squamous cell carcinoma. (See separate leaflet called ‘Cancer of the Skin – Non-melanoma’ for further details about both of these.)

You are also more likely to develop a non-melanoma skin cancer if you have had Bowen’s disease. This is probably due to excessive sun exposure being a risk factor for both Bowen’s disease and non-melanoma skin cancers.

How is Bowen’s disease diagnosed?

Bowen’s disease is usually suspected by its typical appearance on the skin. However, to make a diagnosis, a biopsy (a small sample of your skin) is needed. This allows the skin sample to be examined in a laboratory. Bowen’s disease will have a typical appearance when examined under a microscope.

What is the treatment for Bowen’s disease?

You will usually be referred to a dermatologist (a skin specialist) if you have Bowen’s disease. They will be able to discuss the treatment options with you. There is no definite ‘right way’ to treat all people who have Bowen’s disease. Treatment can depend on a number of different things including the site of the patch of Bowen’s disease, its size and thickness, and how many Bowen’s disease patches you have.

The treatment options include:

Observation (‘watch and wait’)

This may be an option in some people. For example, this may be advised if you have a slowly growing, thin patch of Bowen’s disease on an area of your body where skin healing may be difficult (such as your shin). The skin on your shin is very thin and delicate which means that healing can take longer.

Creams applied to the skin

Certain creams may be used in the treatment of Bowen’s disease. These can help to kill and get rid of the abnormal cells in some cases. Such creams include 5-fluorouracil (5-FU). 5-FU cream may need to be applied once or twice a day for around three to four weeks and sometimes for longer. The cream is easy to apply yourself. The problem is that it can be quite irritant to the skin. Your skin may become red and may actually look worse when you are using the treatment.

Treatment may need to be repeated at a later date if the patch of Bowen’s disease comes back. 5-FU treatment may be particularly useful in large patches of Bowen’s disease or in areas where skin healing may be poor such as your shin (as explained above). It may also sometimes be used in people who have a number of different patches of Bowen’s disease.

Other treatments may be given before treatment with 5-FU cream. This is so that the cream may be absorbed more easily by your skin. These include iontophoresis (where an electrical current drives the cream into your tissues) or laser treatment of your skin.

Imiquimod cream is also sometimes used to treat Bowen’s disease.


Cryotherapy may be a treatment option in some cases. It is a type of ‘freezing’ treatment and usually liquid nitrogen is used. Treatment can sometimes be uncomfortable and ulceration of your skin is a possible side-effect.

Curettage treatment

This is another treatment option. Curettage literally means that the patch of Bowen’s disease is ‘scraped’ off your skin. A local anaesthetic is used to numb your skin for curettage to be done. Your skin is left to heal naturally and usually a scab forms after treatment and then drops off. There may be less pain during curettage treatment than with cryotherapy.


In some cases, surgery to remove the patch of Bowen’s disease may be suggested. For example, surgery is usually carried out for Bowen’s disease around the anus. The patch of Bowen’s disease is cut out from your skin and stitches are used to close up your skin again afterwards. Skin healing may sometimes be difficult, especially when surgery is used to remove patches of Bowen’s disease on the leg below the knee.

Photodynamic therapy

This has been used with some success to treat Bowen’s disease. Most commonly, photodynamic therapy is carried out by applying a special chemical to the patch of Bowen’s disease. The chemical is photosensitive (it reacts to light). A special light source is then directed at the affected patch of skin to activate the photosensitive chemical. This causes substances to be released which can help to break down and destroy the patch of Bowen’s disease. Sometimes burning and stinging of the area of skin being treated can occur and your skin may become irritated. Rarely, skin pigment may be lost or, in some cases, become more pronounced in the treatment area.


Radiotherapy is treatment with X-rays. It is another treatment option for Bowen’s disease but it is less commonly used than other treatments. Again, radiotherapy may not be suitable to treat Bowen’s disease below the knee because of problems with skin healing after treatment.

Laser treatment

This is also sometimes used to treat patches of Bowen’s disease.

What is the prognosis (outlook)?

With most treatments for Bowen’s disease, there is probably about a 1 in 10 chance that Bowen’s disease will recur (come back) after treatment. Therefore, regular follow-up is needed to look for any signs of recurrence. Further treatment may be needed if Bowen’s disease does recur.

Saying that, the outlook for most people with Bowen’s disease is very good. The majority of people who have Bowen’s disease that is recognised and treated will not develop a skin cancer.

Can Bowen’s disease be prevented?

Because excessive sun exposure is one of the risk factors for developing Bowen’s disease, we should all limit our sun exposure in the summer months (or all year when in hot countries nearer the equator) by:

  • Staying indoors or in the shade as much as possible between 11 am and 3 pm.
  • Covering up with clothes and a wide-brimmed hat when out in the sunshine.
  • Applying sunscreen of at least SPF 15 (SPF 30 for children or people with pale skin) which also has high UVA protection.

Please see separate leaflet called ‘Cancer of the Skin – Prevention’ for more details.

If you have had Bowen’s disease, you should make sure that you check your own skin regularly for new patches of Bowen’s disease.

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